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Ovarian Hormone Therapy for Women in the 21st Century

This article was prepared in conjunction with a conference presentation in May 2015. It outlines new information and updates to what is known about ovarian hormone therapy.

Type: 
Articles

Progesterone (not Estrogen) for Hot Flushes in Perimenopausal and Menopausal Women

In less than a year, two influential articles reporting on consensus recommendations for therapy of “menopause-associated” and “menopausal” symptoms concluded that estrogen (with or without progestin) is the optimal therapy.
The purposes of this article are to propose that progesterone therapy is an equally or more effective hot flush/night sweat therapy than estrogen and to show that progesterone is safer than estrogen or estrogen with progestin (a synthetic cousin of progesterone) therapy.

Type: 
Articles
Life Phase: 
Perimenopause, Menopause

Beyond “Estrogen Deficiency”—news from Women’s Health Initiative

When the USA’s National Institutes of Health announced that the Estrogen arm of the Women’s Health Initiative was stopped early, no one could ever say again that estrogen therapy prevents heart disease. Estrogen treatment in women who had undergone hysterectomy was associated with neither benefit nor harm for heart disease and caused a 40% increase in stroke.

Type: 
Articles
Life Phase: 
Menopause

The Death of Hormone Replacement Therapy — Why and how to use Ovarian Hormone Therapy

Dr. Jerilynn C. Prior, Scientific Director of the Centre for Menstrual Cycle and Ovulation Research, has never advocated the use of hormones as an ongoing "replacement" for menopause. She does not feel that menopause is a medical condition that needs to be "fixed". Rather it is a normal stage of life. She strongly advocates use of new term for the few women who do need therapy in menopause. The new term is: Ovarian Hormone Therapy.

Type: 
Articles
Life Phase: 
Menopause

The Estrogen Errors: Why Progesterone Is Better for Women's Health

In this revealing work, Dr. Jerilynn Prior teams up with Susan Baxter, a medical writer, to explain the controversy over medicine prescribing estrogen for perimenopausal women in the United States, and to detail why progesterone is actually a far more effective, and a far less risk-ridden, approach. Citing long-standing and emerging research, patient vignettes, and personal experience, endocrinologist Jerilynn Prior and writer Susan Baxter tell us how false beliefs on estrogen became entrenched in U.S. medicine and culture, and why business and politics have played a role in this erroneous thinking.

Type: 
Book
Life Phase: 
Perimenopause, Menopause

Stopping Estrogen Treatment (Sometimes called “HRT”)

In July 2002, the largest randomized placebo-controlled study of “Hormone Replacement Therapy” for healthy menopausal women was stopped early because it showed that estrogen plus very low dose medroxyprogesterone therapy caused serious harm. Women, when they learned of these results, suddenly stopped their hormone therapy. Many found themselves dealing with severe night sweats and hot flushes.

Type: 
Articles
Life Phase: 
Menopause

Ovarian Hormone Therapy for Women with Early Menopause

We hear a lot of things about hormone therapy (often wrongly called Hormone Replacement Therapy or HRT) (1). Most of the time when “HRT” is used it is referring to the treatment of women who had natural (not surgical) menopause at a normal age. Before about 1998 we believed that estrogen made everything better, but now most of what we hear is bad. And that bad news doesn’t apply to you! Early or surgical menopause needs hormone therapy, but natural, normally timed menopause does not. Some women with early menopause have told me that their doctors stopped their hormone treatment when the Women’s Health Initiative results came out. That’s how confused even doctors are! The purpose of this is to help you feel confident about knowing how and when to take ovarian hormone therapy for a long and healthy life.

Type: 
Articles
Life Phase: 
Menopause

What the Women’s Health Initiative Results Mean for Breast Cancer Survivors

In July 2002 a large, randomized control trial called the Women’s Health Initiative was stopped three years early with the conclusion that Estrogen plus Progestin (E+P) is, on balance, not an effective preventative medication for healthy menopausal women. The results of this trial have surprised both doctors and the general public, because they have shown that E+P does not prevent heart disease and causes breast cancer (1). We believe there are several changes in concepts about menopausal hormone therapy that are important for breast cancer survivors.

Type: 
Articles
Life Phase: 
Perimenopause, Menopause

WHI, Five Years Later–WHY no Change

The Women’s Health Initiative (WHI) Estrogen plus Progestin (E plus P) trial was prematurely stopped because it caused harm (1). Until the Estrogen in women with hysterectomy arm (E only) of the WHI was also halted prematurely in 2004 (2), progestin was blamed for the lack of heart disease prevention. But now, five years later, doctors and media are still discussing Hormone Replacement Therapy (HRT) and menopause as estrogen deficiency. The fundamental question is: Given these huge, great science WHI studies showing harm is caused by HRT, why has medicine not changed?

Type: 
Articles
Life Phase: 
Perimenopause, Menopause

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Enrolment complete: Perimenopausal Hot Flush Study

Enrolment is now complete. Thank you for your interest.
CeMCOR is now recruiting Canadian women for this CIHR-funded randomized controlled trial to test whether oral micronized progesterone is more effective than placebo as therapy for hot flushes and night sweats in perimenopausal women.

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